Receptor binding properties of KW-3049, a new 1, 4-dihydropyridine calcium channel blocker
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چکیده
منابع مشابه
Evaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
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Aim. Dihydropyridine calcium channel blockers (CCB) are widely preferred for the treatment of hypertension for their efficacy, metabolic neutrality and low side effect profile. However pedal edema formation limits their usage. The aim of the present study is to evaluate the incidence of pedal edema formation with a different dihydropyridine CCB in hypertensive patients who developed pedal edema...
متن کاملevaluation of mutagenicity of mebudipine, a new calcium channel blocker
mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...
متن کامل1,4-Dihydropyridine binding sites in moss plasma membranes. Properties of receptors for a calcium channel antagonist.
An increase in cytoplasmic calcium is an early event in hormone (cytokinin)-induced vegetative bud formation in the moss Physcomitrella patens. Whole cell and calcium transport studies have implicated 1,4-dihydropyridine-sensitive calcium channels in this increase in cellular calcium. To understand the molecular nature of the dihydropyridine-sensitive calcium channel, we have established condit...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1986
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)59041-2